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Leuprorelin Hormone Therapy for Prostate and Breast Cancer
Leuprorelin Hormone Therapy for Prostate and Breast Cancer
Leuprorelin Hormone Therapy for Prostate and Breast Cancer

Leuprorelin Hormone Therapy for Prostate and Breast Cancer

Reference price:USD 30-100

  • Product name Leuprorelin
  • CAS No. 53714-56-0
  • Density 1.44
  • Melting point 150-155°C
  • Boiling point 1720.5°C at 760 mmHg
  • MF C59H84N16O12
  • MW 1269.473
  • Refractive index 1.681
  • Flash point 994.3°C
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product details

Detailed Description

Leuprorelin, also known as Lupron or Prostap, is a hormone therapy used in the treatment of prostate and breast cancer. It belongs to a class of medications called gonadotropin-releasing hormone (GnRH) agonists. In this essay, we will focus on its use in prostate and breast cancer treatment.

Prostate Cancer Treatment:
Leuprorelin is commonly used to treat advanced prostate cancer. It functions by lowering the level of testosterone produced by the testicles. Prostate cancer cells depend on testosterone for growth, so reducing its levels can shrink the cancer or slow its growth. The administration of leuprorelin helps manage the symptoms associated with advanced prostate cancer and improves the patient's quality of life.

Breast Cancer Treatment:
Leuprorelin is also utilized in the treatment of certain types of breast cancer. It is specifically used in cases where the cancer cells have estrogen receptors (ER positive) and the patient has not gone through menopause. Leuprorelin reduces the level of estrogen in the body by suppressing its production in the ovaries. This is crucial because high levels of estrogen can promote the growth of breast cancer cells. Leuprorelin may be administered alone or in combination with other hormone therapies to effectively manage breast cancer.


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Central Precocious Puberty:

Leuprorelin injection, known as Lupron Depot-PED, is used in children aged 2 years and older to treat central precocious puberty (CPP). CPP is a condition in which girls (usually younger than 8 years of age) and boys (usually younger than 9 years of age) enter puberty prematurely. Leuprorelin helps regulate the timing of puberty by slowing down the rapid bone growth and development of sexual characteristics associated with CPP.


Other Clinical Uses:

Leuprorelin injection, also known as Lupron Depot, is utilized in the treatment of endometriosis and anemia caused by uterine fibroids. It works by decreasing the levels of certain hormones in the body, offering relief from symptoms such as pain, heavy or irregular menstruation, and anemia. Additionally, leuprorelin can be used as a medical pre-treatment before endometrial resection, as it thins the endometrium, reduces edema, and facilitates the surgical procedure.


Pharmacokinetics:
Leuprorelin acetate is not effective when taken orally and is instead administered via subcutaneous or intramuscular injection. Following a single subcutaneous injection of 3.75 mg, the peak plasma concentration is reached within 1 to 2 days, with levels of 1 to 2 ng/ml. In prostate cancer treatment, a subcutaneous injection of 3.75 mg is given every 4 weeks for a total of 3 injections to achieve steady-state plasma concentrations of 0.1 to 1 ng/ml. Leuprorelin is metabolized into four degradation products in the body and excreted primarily through the kidneys.

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Conclusion:
Leuprorelin, a GnRH agonist, is a valuable hormone therapy used in the treatment of prostate and breast cancer, as well as central precocious puberty, endometriosis, and anemia caused by uterine fibroids. By reducing testosterone or estrogen levels, leuprorelin helps control the growth and symptoms associated with these conditions. The administration of leuprorelin requires medical supervision and regular monitoring to ensure its effectiveness and manage any potential side effects.

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Specification

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