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Paroxetine Powder Paroxetine Hydrochloride Raw Material Paroxetine Hcl

  • Product Name Paroxetine
  • Appearance White to off-white powder
  • CAS No. 61869-08-7
  • Chemical Formula C19H20FNO3
  • Molecular weight 329.365403
  • Melting point 118 - 125 C
  • Boiling point 451.674 °C at 760 mmHg
  • Density 1.213
  • Refractive index 1.561

Detailed Description

Paroxetine is commonly used as its hydrochloride or methanesulfonate.Hydrochloride is white or off-white,easily deliquescent crystalline powder,easily soluble in methanol,slightly soluble in absolute ethanol and methylene chloride,and slightly soluble in water.Methanesulfonate is an off-white powder,odorless,solubility in water>1g/ml,melting point 147~150℃.
Paroxetine is an important medication used to treat a variety of mental health conditions,it is a phenylpiperidine derivative and an SSRI that can selectively inhibit the 5-HT transporter,block the reuptake of 5-HT by the presynaptic membrane,prolong and increase the effect of 5-HT,thereby producing antidepressant effect.Its primary function is to act as an antidepressant and anxiolytic agent by selectively inhibiting the reuptake of serotonin in the brain.Serotonin is a neurotransmitter that plays a crucial role in regulating mood,emotions,and anxiety levels.By blocking the reuptake of serotonin,Paroxetine helps to increase the levels of serotonin in the brain,thereby improving mood and reducing anxiety.

Paroxetine is also used in the treatment of other mental health conditions such as obsessive-compulsive disorder(OCD),panic disorder,social anxiety disorder,and post-traumatic stress disorder(PTSD).Its mechanism of action in these conditions is similar to its role in treating depression and anxiety.By increasing serotonin levels in the brain,Paroxetine helps to alleviate the symptoms associated with these disorders.


The applications of Paroxetine encompass a wide range of mental health conditions,making it a versatile and valuable medication.As an antidepressant,Paroxetine is used to alleviate the symptoms of major depressive disorder,including persistent sadness,loss of interest in usual activities,changes in appetite or weight,sleep disturbances,and feelings of worthlessness or guilt.In the treatment of anxiety disorders,Paroxetine is effective in reducing the symptoms of generalized anxiety,social anxiety,and panic disorders.It helps to alleviate excessive worry,fear of social situations,and panic attacks,allowing individuals to regain control over their emotions and daily functioning.

For patients with OCD,Paroxetine plays a crucial role in managing the obsessions and compulsions that interfere with their daily lives.By modulating serotonin levels,Paroxetine helps to reduce the frequency and intensity of obsessive thoughts and compulsive behaviors,enabling individuals to engage in their daily activities more comfortably.Moreover,Paroxetine is also utilized in the treatment of PTSD,where it aids in mitigating the distressing symptoms associated with traumatic experiences,such as intrusive thoughts,nightmares,hypervigilance,and avoidance behaviors.Additionally,Paroxetine is used off-label in the management of other conditions such as premenstrual dysphoric disorder(PMDD),vasomotor symptoms associated with menopause,and various pain syndromes.These diverse applications demonstrate the significance of Paroxetine in addressing a wide array of mental health challenges.

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