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Rosuvastatin antilipemic agent Rosuvastatin treat dyslipidemia

Reference price: USD 5-10/g

  • Product Name Rosuvastatin
  • CAS No. 287714-41-4
  • MF C22H28FN3O6S
  • MW 481.54
  • EINECS 689-191-5
  • Density 1.368±0.06 g/cm3(Predicted)
  • Melting point 161.9 °C

Detailed Description

Rosuvastatin is commonly prescribed medications used to treat hypercholesterolemia and related conditions. This drug, known as statins, are used in combination with exercise, diet control, and weight loss to improve cholesterol levels and prevent cardiovascular disease. This essay will explore the mechanisms of action and clinical uses of rosuvastatin, along with its effects on lipid abnormalities and overall cardiovascular health.

Rosuvastatin, classified as an antilipemic agent and a member of the statin class of medications, is primarily used to treat dyslipidemia, including high cholesterol. It works by blocking an enzyme involved in cholesterol production in the body, leading to reduced levels of total cholesterol and triglycerides, while simultaneously increasing levels of high-density lipoprotein (HDL) cholesterol, often referred to as "good" cholesterol. Rosuvastatin is most effective when combined with a healthy diet and exercise program. Additionally, it is used to treat individuals with certain inherited cholesterol disorders. Clinical uses of rosuvastatin include the treatment of primary hypercholesterolemia, familial hypercholesterolemia, and lipid disorders caused by other factors.


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Rosuvastatin inhibits the enzyme hydroxymethylglutaryl-CoA reductase in the liver, which reduces cholesterol synthesis and lowers serum cholesterol and triglyceride levels. Moreover, Rosuvastatin increases the liver's uptake and breakdown of low-density lipoprotein cholesterol (LDL-C), while also raising the levels of high-density lipoprotein cholesterol (HDL-C). In addition to its lipid-lowering effects, Rosuvastatin has been shown to possess anti-atherosclerotic, anti-inflammatory, antioxidant, plaque stabilizing, and improved endothelial function properties.

Rosuvastatin is produced via fermentation of Aspergillus terreus or through chemical synthesis. Once ingested, it is extensively metabolized in the liver and converted into various metabolites, including active metabolites that inhibit HMG-CoA reductase. The drug and its metabolites are primarily excreted in feces, with a small amount excreted in urine.


By competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, lovastatin reduces endogenous cholesterol production and increases the expression of LDL receptors in liver cells. This results in an increased clearance rate of LDL cholesterol. Lovastatin also helps lower serum triglyceride levels and increase levels of HDL cholesterol, contributing to the prevention and treatment of atherosclerosis and cardiovascular disease.

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Rosuvastatin is valuable medications for the treatment of hypercholesterolemia and related conditions. Rosuvastatin primarily acts by blocking cholesterol production and improving cholesterol levels in combination with lifestyle modifications. On the other hand, inhibits cholesterol synthesis and increases the liver's uptake and breakdown of LDL cholesterol, resulting in decreased cholesterol and triglyceride levels. It have demonstrated efficacy in improving lipid abnormalities and overall cardiovascular health. It is important to consult with us for a  healthcare professional guide to determine the appropriate use and dosage of these medications based on individual needs and medical history.

Specification

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