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Telmisartan Better antihypertensive Protecting renal

Reference price: USD 0.2-0.8/g

  • Product Name Telmisartan
  • CAS No. 144701-48-4
  • MF C33H30N4O2
  • MW 514.629
  • EINECS 1592732-453-0

Detailed Description

Telmisartan, also known as Timosartan, is a novel blood pressure-lowering drug classified as a specific angiotensin II receptor (AT1-type) antagonist. It is widely used in the treatment of essential hypertension, offering several advantages over other antihypertensive medications. This essay aims to provide a comprehensive overview of the benefits of Telmisartan and important considerations for its use.

Advantages of Telmisartan:

Better antihypertensive effect:
Telmisartan is a commonly prescribed first-line antihypertensive drug due to its high efficacy. As an AT1-type antagonist, it inhibits the action of angiotensin, resulting in a significant reduction in blood pressure. Telmisartan exhibits a higher degree of specificity compared to other sartans, allowing it to easily penetrate cell membranes and target specific cells. This specificity enhances its antihypertensive effects, leading to a substantial decrease in blood pressure. Additionally, Telmisartan has a longer half-life, ensuring sustained and effective blood pressure control.

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Protection of cardiovascular and cerebral vessels:

Telmisartan stands out as the only sartan-like drug approved by the FDA for its cardiovascular and cerebrovascular protective properties. It demonstrates the ability to reverse left ventricular hypertrophy and is recommended for patients with hypertension accompanied by left ventricular hypertrophy, cardiac insufficiency, or coronary artery disease. In addition to its blood pressure-lowering effects, Telmisartan reduces cardiovascular and cerebrovascular damage. It is particularly beneficial for individuals who have experienced a stroke or cardiac infarction.

Protecting renal function:

Another advantage of Telmisartan is its favorable impact on renal function. Since Telmisartan undergoes hepatic metabolism and is excreted in bile, it has minimal impact on renal function. Moreover, Telmisartan has been found to reduce proteinuria, thereby safeguarding renal function. It is particularly useful in patients with hypertension and comorbid conditions such as diabetic nephropathy, microalbuminuria, proteinuria, or mild to moderate renal insufficiency.

Improvement of insulin resistance:

Telmisartan has demonstrated positive effects on glucose metabolism and insulin resistance. This characteristic makes it a suitable option for patients with hypertension and diabetes mellitus, as it can help improve insulin sensitivity and glucose control.


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Telmisartan, a specific angiotensin II receptor (AT1-type) antagonist, offers several advantages in the treatment of essential hypertension. Its better antihypertensive effect, protection of cardiovascular and cerebral vessels, preservation of renal function, and improvement of insulin resistance make it a valuable choice in managing hypertension and associated conditions. However, it is crucial to follow recommended guidelines regarding medication timing, dosage control, and regular monitoring to ensure optimal efficacy and safety. Consultation with a healthcare professional is always advised for personalized advice and guidance regarding the use of Telmisartan or any medication.

Specification

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